Clinical Trials
Clinical Trials Available at USC Dept of Neurosurgery
Brain Cancer Studies
For more information on the clinical trial, please read the informed consent
- NovoCure: A Prospective, Multi-center Trial of NovoTTF-100A Together With Temozolomide Compared to Temozolomide Alone in Patients with Newly Diagnosed GBM — Watch NovoCure video in WMV format or in MPG format English Consent/Spanish Consent
- EMD Serano: 6G-09-1-Cilengitide for Subjects with newly Diagnosed Glioblastoma Multiforme and Methylated MGMT Gene Promoter – a Multicenter, Open-label, Controlled Phase III Study, Testing Cilengitide in Combination with Standard Treatment (Temozolomide with Concomitant Radiation Therapy, Followed by Temozolomide Maintenance Therapy) versus Standard Treatment Alone (CENTRIC)
- RTOG-8205: Phase III Double-Blind Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab Versus Conventional Concurrent Chemoradation and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma English Consent/Spanish Consent
- USC CNS Repository: Establishment of USC CNS and Spine Tumor Bank English Consent/Spanish Consent
- ERC: Tissue, Collection, Storage, and Distribution English Consent
Spine Studies
- Sanofi Randomized, double-blind, placebo-controlled study of the effect of a single injection of SAR164877 (REGN475) on reduction of pain from vertebral fracture associated with osteoporosis. English Consent/Spanish Consent
- Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) versus open transforaminal lumbar interbody fusion (TLIF): Comparison of post-surgical paraspinal muscle atrophy, muscle fatigability, and functional outcomes between the two techniques English Consent/Spanish Consent
- Synthes: Use of chronOS for spinal fusion after decompression for lumbar stenosis English Consent/Spanish Consent
- Orthofix: Post-Market Surveillance of Clinical and Functional Outcomes with Post-Operative Adjunctive Use of Cervical-Stim or Spinal-Stim English Consent
- The Clinical and Radiographic Outcomes of Anterior Lumbar Interbody Fusion Using A Novel Stand-Alone Interbody Fusion Device - (ROI-A) A prospective, non-randomized multi-centered study. English Consent/Spanish Consent
Traumatic Brain Injury
- BHR: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study to Investigate the Efficacy and Safety of Progesterone in Patients with Severe Traumatic Brain Injury. English Consent/Spanish Consent
Device Studies
- Micrus Endovascular Corporation: Vitesse Intracranial Stent Study for Ischemic Therapy – This study looks at the safety, benefit, and effectiveness of the PHAROS Vitesse Neurovascular Stent System to treat intracranial stenosis in patients with recent stroke or TIA and is compared to standard treatment of maximum medical therapy. English Consent/Spanish Consent
- Enterprise Stent (FDA-Humanitarian Use Device (HUD))- This is a stent used to assist in endovascular coil embolization of wide-necked intracranial aneurysms ,ruptured and un-ruptured . Sponsor – Cordis Endovascular
- Onyx HD-500 (FDA-Investigational Device Exemption (IDE) – A non-adhesive liquid embolic agent used for embolization of large and giant, wide-necked aneurysms. Sponsor- Ev3 Neurovascular
- The Neuroform Microdelivery Stent (HUD) - This is a stent used to assist in the endovascular coil embolization of wide-necked intracranial aneurysms. Boston Scientific
- Wingspan Stent System with Gateway PTA Balloon Catheter(HUD) – indicated in use for improving cerebral artery lumen in patients with intracranial atherosclerotic disease, refractory to medical therapy in intracranial vessels with greater than or equal to 50% stenosis that are accessible to the system. Boston Scientific
Studies in Development
- ACRIN 6684 - Multicenter, Phase II Assessment of Tumor Hypoxia in Glioblastoma Using 18F-Fluoromisonidazole (FMISO) With PET and MRI
- PAC Study – Resistry to assess angiographic outcomes of endovascular treatment of large and giant aneurysms using Cerecyte and Presidio coils.
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Micrus Endovascular Corporation H-CAT Study – Study compares clinical and angiographic outcomes in patients receiving Hydrocoils versus Cerecyte coils in patients with ruptured or un-ruptured aneurysms 5-20mm in size. Study sponsor – MicroVention, Inc.
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A Prospective, Concurrently-controlled, Multi-center Pivotal Clinical Trial for INFUSE® Bone Graft with the CAPSTONE® Spinal System and Posterior Supplemental Fixation for the Treatment of One-level or Two-level Symptomatic Advanced Degenerative Disease of the Lumbosacral Spine Utilizing a Transforaminal Lumbar Interbody Fusion (TLIF) Approach.
