Research grants for neurosurgical research

Research Grants

Apuzzo: Radiosurgical Treatment of Temporal Epilepsy, Award # 29985C

Wang: Depuy Acromed restricted research grant (2004): HEALOS and bone marrow aspirate in long construct anterior cervical fusions.

Wang: Depuy Acromed restricted research grant (2003): Determining the anatomic constraints of the C1 lateral mass for screw placement, including screw entry points, lengths, and trajectories.

Wang: Sofamor Danek restricted research grant (2003): Clinical outcomes from the application of resorbable cervical interbody spacers.

Liker: Co-Investigator with the Cortical Prosthesis Testbed component of the Biomimetic Microelectronic Systems (BMES) Engineering Research Center (ERC) at USC sponsored by the NSF. The goal of the Cortical Prosthesis Testbed is to develop next-generation biomimetic neural prostheses that communicate bi-directionally with cortical brain regions to replace the function of brain areas lost due to damage or disease.

Liker: Co-Investigator (IRB submitted and pilot initiated) Monitoring the visual axis during posterior spine surgery. Impetus for the study is the rare instance of blindness (Posterior ischemic optic neuropathy - PION) during extensive posterior spinal surgery.

Liker: Role of dopamine agonist versus carbidopa/levodopa in glutamine release in the basal ganglia of MPTP lesioned murine and primate models of Parkinson's disease.

Liker: Role of exercise in plasticity of the basal ganglia. Using microdialysis to assess dopamine changes in the basal ganglia following a vigorous exercies regimen in murine models of Parkinson’s disease.

Chen: “Non-Invasive, Cell Proliferation-Based Assessment Treatment Response in Human Malignant Gliomas With Positron Emission Tomography” The Dana Foundation 2003-2006, Principal Investigator

Chen: A Phase III multicenter study of intratumoral/interstitial therapy with TransMID. Xenova Group.5-2004 to 5-2005, Principal Investigator

Chen: Phase III Randomized Evaluation of Convection Enhanced Delivery of IL13-PE38QQR Compared to Gliadel. NeoPharm, Inc. 6-2004 to 6-2005, Principal Investigator

Chen: Can the platelet plug be used safely in cancer patients? DePuy Acromed, Inc. 2004 – 2005, Principal Investigator

Chen: In-vivo imaging of replication competent retrovirus transduction of malignant gliomas using micro-positron emission tomography. P20 grant awarded to Peter Conti, MD, PhD Development of a cellular and molecular based cancer imaging center. 2003 - 2004, Principal Investigator

Chen: Role of PKC-Mediated GRP Induction in Glioma Chemoresistance. National Cancer Institute, co-PI 7-2003 to 7-2006, co-PI

Chen: Generating Brain Tumor Targeted Derivatives of the Anti-Tumor Drug Celecoxib. James H. Zumberge Research and Innovation Fund, PI 7-1-2004 to 7-31-2005, Principal Investigator

Gruen: Hypothermia for Severe Head Injury. One of 10 centers. University of Texas (Guy Clifton) Coordinating Center. NIH funded study.

Gruen: Bactiseal catheter study with Codman. Antibiotic impregnated ventricular catheters versus plain catheters comparison of infection rates.

Gruen: Hypopituitarism following severe head injury. One of 3 centers NIH grant.

Liu: Engineering of the Extracellular Matrix for Neural Stem Cell Programming and Neurorestoration. Agency: Congress of Neurological Surgeons/Margot Anderson Foundation, Role: PI, Duration: 7/1/03-1/1/04

Liu: Extracellular Matrix Proteins for Neural Stem Cell Programming and Restoration of the Aging and Degenerating Nervous System, NIH-NIA, Role: PI, Duration: 4/1/03-3/31/04

Liu: Engineering of the Extracellular Matrix – Artificial Extracellular Matrix Proteins for Neural Stem Cell Programming, Donald E. and Delia B. Baxter Foundation, Role: PI, Duration: 7/1/03-6/30/04

Liu: Artificial Niches for Neural Stem Cells, American Association of Neurological Surgeons – Neurosurgical Research and Education Foundation, Role: PI, Duration: 7/1/04-6/30/05

Giannotta: Familial Intracranial Aneurysm. University of Cincinnati

Giannotta: Cerebral Aneurysm Rerupture Study. UCSF

Giannotta: Temperature Control during Aneurysm Surgery. Innercool Therapies

Giannotta: Hypothermia during Intracranial Aneurysm Surgery. Univ. of Iowa

Larsen: CREST – Carotid endarterectomy vs. Carotid angioplasty and stenting: A randomized multicenter national trial.

Research Grants Apuzzo: Radiosurgical Treatment of Temporal Epilepsy, Award # 29985C Wang: Depuy Acromed restricted research grant (2004): HEALOS and bone marrow aspirate in long construct anterior cervical fusions. Wang: Depuy Acromed restricted research grant (2003): Determining the anatomic constraints of the C1 lateral mass for screw placement, including screw entry points, lengths, and trajectories. Wang: Sofamor Danek restricted research grant (2003): Clinical outcomes from the application of resorbable cervical interbody spacers. Liker: Co-Investigator with the Cortical Prosthesis Testbed component of the Biomimetic Microelectronic Systems (BMES) Engineering Research Center (ERC) at USC sponsored by the NSF. The goal of the Cortical Prosthesis Testbed is to develop next-generation biomimetic neural prostheses that communicate bi-directionally with cortical brain regions to replace the function of brain areas lost due to damage or disease. Liker: Co-Investigator (IRB submitted and pilot initiated) Monitoring the visual axis during posterior spine surgery. Impetus for the study is the rare instance of blindness (Posterior ischemic optic neuropathy - PION) during extensive posterior spinal surgery. Liker: Role of dopamine agonist versus carbidopa/levodopa in glutamine release in the basal ganglia of MPTP lesioned murine and primate models of Parkinson's disease. Liker: Role of exercise in plasticity of the basal ganglia. Using microdialysis to assess dopamine changes in the basal ganglia following a vigorous exercies regimen in murine models of Parkinson’s disease. Chen: “Non-Invasive, Cell Proliferation-Based Assessment Treatment Response in Human Malignant Gliomas With Positron Emission Tomography” The Dana Foundation 2003-2006, Principal Investigator Chen: A Phase III multicenter study of intratumoral/interstitial therapy with TransMID. Xenova Group.5-2004 to 5-2005, Principal Investigator Chen: Phase III Randomized Evaluation of Convection Enhanced Delivery of IL13-PE38QQR Compared to Gliadel. NeoPharm, Inc. 6-2004 to 6-2005, Principal Investigator Chen: Can the platelet plug be used safely in cancer patients? DePuy Acromed, Inc. 2004 – 2005, Principal Investigator Chen: In-vivo imaging of replication competent retrovirus transduction of malignant gliomas using micro-positron emission tomography. P20 grant awarded to Peter Conti, MD, PhD Development of a cellular and molecular based cancer imaging center. 2003 - 2004, Principal Investigator Chen: Role of PKC-Mediated GRP Induction in Glioma Chemoresistance. National Cancer Institute, co-PI 7-2003 to 7-2006, co-PI Chen: Generating Brain Tumor Targeted Derivatives of the Anti-Tumor Drug Celecoxib. James H. Zumberge Research and Innovation Fund, PI 7-1-2004 to 7-31-2005, Principal Investigator Gruen: Hypothermia for Severe Head Injury. One of 10 centers. University of Texas (Guy Clifton) Coordinating Center. NIH funded study. Gruen: Bactiseal catheter study with Codman. Antibiotic impregnated ventricular catheters versus plain catheters comparison of infection rates. Gruen: Hypopituitarism following severe head injury. One of 3 centers NIH grant. Liu: Engineering of the Extracellular Matrix for Neural Stem Cell Programming and Neurorestoration. Agency: Congress of Neurological Surgeons/Margot Anderson Foundation, Role: PI, Duration: 7/1/03-1/1/04 Liu: Extracellular Matrix Proteins for Neural Stem Cell Programming and Restoration of the Aging and Degenerating Nervous System, NIH-NIA, Role: PI, Duration: 4/1/03-3/31/04 Liu: Engineering of the Extracellular Matrix – Artificial Extracellular Matrix Proteins for Neural Stem Cell Programming, Donald E. and Delia B. Baxter Foundation, Role: PI, Duration: 7/1/03-6/30/04 Liu: Artificial Niches for Neural Stem Cells, American Association of Neurological Surgeons – Neurosurgical Research and Education Foundation, Role: PI, Duration: 7/1/04-6/30/05 Giannotta: Familial Intracranial Aneurysm. University of Cincinnati Giannotta: Cerebral Aneurysm Rerupture Study. UCSF Giannotta: Temperature Control during Aneurysm Surgery. Innercool Therapies Giannotta: Hypothermia during Intracranial Aneurysm Surgery. Univ. of Iowa Larsen: CREST – Carotid endarterectomy vs. Carotid angioplasty and stenting: A randomized multicenter national trial.